For a free electronic reprint of any Burke Group publication, please email Ramona Rudzinski at

61. Lewandowska, A.; Soutar, C.P.; Greenwood, A.I.; Nimerovsky, E.; De Lio, A.M.; Holler, J.T.; Hisao, G.S.; Khandelwal, A.; Zhang, j.; SantaMaria, A.M.; Schwieters, C.D.; Pogorelov, T.V.; Burke M.D.; Rienstra, C.M. “Fungicidal Amphotericin B Sponges are Assemblies of Staggered Asymmetric Homodimers Encasing Large Void Volumes” Nature Structural & Molecular Biology 2021 in press

60. Ranoa, D.R.E.; Holland, R.L.; Alnaji, F.G.; Green, K.J.; Wang, L.; Fredrickson, R.L; ~130 additional authors… Sullivan W.C.; Smith, R.L.; Goldenfeld, N.D.; Fan, T.M.; Hergenrother, P.J.; Burke, M.D. “Mitigation of SARS-CoV-2 Transmission at a Large Public University” medRxiv 2021
59.Wang, H.; Li, W.; Jin, X.; Cho, K.; Ji, H.; Han, J.; Burke, M. D. “Chemical-Reaction-Aware Molecule Representation Learning” arXiv 2021
58. Morelle, C.; Mukherjee, A.; Zhang, J.; Fani, F.; Khandelwal, A.; Gringras, H.; Trottier, J.; Barbier, O.; Leprohon, P.; Burke, M. D.; Ouelette, M. “Well-tollerated amphotericin B derivatives that effectively treat visceral leishmaniasis” ACS Infect. Dis. 2021, 7, 2472-2482.
57. Li, S.; Yu, H.; Li, J.; Angello, N.; Jira, E. R.; Li, B.; Burke, M. D.; Moore, J. S.; Schroeder, C. M. “Transition between nonresonant and resonant charge transport in molecular junctions” Nano Lett. 2021 ASAP.
56. Guo, X.; Zhang, J.; Li, X.; Xiao, E.; Lange, J.D.; Rienstra, C.M.; Burke, M.D.; Mitchell, D.A. “Sterol Sponge Mechanism is Conserved for Glycosylated Polyene MacrolidesACS Central Science, 2021
55. Chorghade, R.S.; Kim, B.R.; Launspach, J.L.; Karp, P.H.; Welsh, M.J.; Burke, M.D.; “Amphotericin B induces epithelial voltage responses in people with cystic fibrosis” Journal of Cystic Fibrosis, 2020
53. Ranoa, D.R.E.; Holland, R.L., Alnaji, F.G.; Green, K.J.; Wang, L.; Brooke, C.B., Burke, M.D., Fan, T.M.; Hergenrother, P.J. “Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction” 2020.
51. Kelly, A. M.; Chen P.-J.; Klubnick J.; Blair, D. J.; Burke, M. D.; “A Mild Method for Making MIDA Boronates” Organic Letters 2020 22 (24), 9408-9414
50. Hou, J.; Daniels, P. N.; Burke, M. D.; “Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast” ACS Chemical Biology 2020, 15, 1575-1580.

49. A Computer Conquers Tactical Combinations Blair, D. J. & Burke, M. D., Jan 9 2020, In : Chem. 6, 1, p. 12-13 2 p.

48. Jo. Y-I.; Burke, M.D.; and Cheon, C-H. “Modular Syntheses of Phenanthroindolizidine Natural Products” Organic Letters 21, 11, 4201–4204, 2019.
[pdf][full text]

  1. Lehmann, J.; Crouch, I.; Blair, D.; Trobe, M.; Wang, P.; Li, J.; and Burke, M.D. “Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids” Nature Communications 2019, 10, 1263
    [pdf][full text]
  1. Muraglia, K.A.; Chorghade, R.S.; Kim, B.R.; Tang, X.X.; Shah, V.S.; Grillo, A.S.; Daniels, P.N.; Cioffi, A.G.; Karp, P.H.; Zhu, L.; Welsh, M.J.; and Burke, M.D. “Small molecule ion channel restores host defenses in cystic fibrosis airway epithelia” Nature 2019567, 405-408.
    [pdf][full text]
  • Highlighted in Science,“Antifungal drug could help cystic fibrosis patients for whom common treatments don’t work”
  • Highlighted in Nature, “Pore-forming small molecules offer a promising way to tackle cystic fibrosis”
  • Highlighted in Chemical and Engineering News, “Amphotericin B improves cystic fibrosis symptoms in cultured cells and pigs”
  • Highlighted in Carle Illinois College of Medicine, “Potential new cystic fibrosis treatment uses ‘molecular prosthetic’ for missing lung protein”
  • Highlighted in NIH News Releases, “Scientists find new approach that shows promise for treating cystic fibrosis”
  • Highlighted in Science Daily, “Potential cystic fibrosis treatment uses ‘molecular prosthetic’ for missing lung protein”
  • Highlighted in Illinois Public Media News, “New U of I Research Points to Possible Cystic Fibrosis Treatment”
  • Highlighted in Technology Networks, “Common Anti-fungal Drug Considered for Use in Cystic Fibrosis”
  • Highlighted in Iowa City Press Citizen, “Two UIs work together on cystic fibrosis breakthrough”
  • Highlighted in Chemistry World, “Hole-punching antifungal used as molecular prosthesis for cystic fibrosis”
  • Highlighted in University of Iowa Health Care, “Illinois-Iowa study points to promising CF treatment”
  • Highlighted in Cystic Fibrosis News Today, “Amphotericin Holds Promise as Treatment for All CF Patients, Preliminary Study Shows”
  • Highlighted in Pharmaceutical Technology News, “Common antifungal drug offers hope for cystic fibrosis treatment”
  • Highlighted in NIH Research Matters, “Replacing function of impaired cystic fibrosis protein”
  • Highlighted in Pulmonology Advisor, “Small-Molecule Ion Channels Restore Host Defenses in CF Airway Epithelia”
  • Highlighted in WCIA News, “Possible new treatment for cystic fibrosis”
  • Highlighted in RxNet, “Could molecular prosthetics lead to drugs for all cystic fibrosis patients?: an interview with Martin Burke”
  • Highlighted in Medicom, “Amphotericin B makes path for lung defense in cystic fibrosis”
  1. Haley, H.M.S.; Hill, A.G.; Greenwood, A.I.; Woerly, E.M.; Rienstra, C.M.; Burke, M.D.; “Peridinin is an exceptionally potent and membrane-embedded inhibitor of bilayer lipid peroxidation” Journal of American Chemical Society 2018140(45), 15227-15240.
    [pdf][full text]
  1. Yien, Y.Y.; Shi, J.; Chen, C.; Cheung, J.T.M.; Grillo, A.S.; Shrestha, R.; Li, L.; Zhang, X.; Kafina, M.D.; Kingsley, P.D.; King, M.J.; Albain, J.; Li, H.; Zon, L.I.; Palis, J.; Burke, M.D.; Bauer, D.E.; Orkin, S.H.; Koehler, C.M.; Phillips, J.D.; Kaplan, J.; Ward, D.M.; Lodish, H.F.; Paw, B.H.; “FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity” Journal of Biological Chemistry 2018293, 19797-19811.
    [pdf][full text]
  1. Lehmann, J.W.; Blair, D.J.; Burke, M.D.; “Towards the generalized iterative synthesis of small molecules” Nature Review Chemistry 2018, 2, 0115.
    [abstract][pdf][full text]
  1. Trobe, M.; Burke, M.D.; “The molecular industrial revolution: automated synthesis of small molecules” Angewandte Chemie 2018, 57, 4192-4214.
    [pdf][full text]
  1. Della Ripa, L.A.; Petros, Z.A.; Cioffi, A.G.; Piehl, D.W.; Courtney, J.M.; Burke, M.D.; and Rienstra, C.M. “Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers” Methods 2018138-139; 47-53.
    [pdf][full text]
  1. Grillo, A.S.; SantaMaria, A.M.; Kafina, M.D.; Cioffi, A.G.; Huston, N.C.; Han, M.; Seo, Y.A.; Yien, Y.Y.; Nardone, C.; Menon, A.V.; Fan, J.; Svoboda, D.C.; Anderson, J.B.; Hong, J.D.; Nicolau, B.G.; Subedi, K.; Gewirth, A.A.; Wessling-Resnick, M.; Kim, J.; Paw, B.H.; Burke, M.D.; “Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals” Science 2017, 356, 608-616.
    [abstract][pdf][full text][supp info]

  • Highlighted in Science, “Iron Man Molecule Restores Balance to Cells”
  • Highlighted in Nature, “Small molecule shuttles iron into cells”
  • Highlighted in C&EN, “Molecular prosthetic moves iron into, out of, and within cells”
  • Highlighted American Chemical Society, “Molecule of the Week: Hinokitiol”
  • Highlighted in Cystic Fibrosis News, “Cypress-tree Substance Could Help Skirt Faulty Proteins in Cystic Fibrosis”
  • Highlighted in Harvard News, “Iron-transporting molecule could help reduce anemia”
  • Highlighted in ACS Chemical Biology, “Small Molecule Shuttles Iron Across Cellular Membranes”
  • Highlighted in EurekAlert!, “‘Molecular prosthetics’ can replace missing proteins to treat disease”
  • Highlighted in Cosmos, “‘Molecular prosthetic’ replaces function of missing proteins”
  • Highlighted in Today’s Science, “Pumping Iron: A New Molecule for Iron Deficiency”
  • Highlighted in Illinois News Bureau, “‘Molecular prosthetics’ can replace missing proteins to treat disease”
  • Highlighted in ScienceDaily, “Compound corrects iron-delivery defects”
  • Highlighted in ScienceDaily, “‘Molecular prosthetics’ can replace missing proteins to treat disease”
  • Highlighted in Sciences et Avenir, “La molécule Iron Man pourrait guérir de nombreuses maladies”
  • Highlighted in Science Newsline, “‘Molecular Prosthetics’ Can Replace Missing Proteins to Treat Disease”
  • Highlighted in Vector, “Naturally-occurring molecule in tree leaves could treat anemia, other iron disorders”
  • Highlighted in R&D, “New Molecule Could Help Treat Anemia”
  • Highlighted in Cluster Salud, “Las ‘prótesis moleculares’ pueden reemplazar las proteínas que faltan para tratar enfermedades”
  • Highlighted in Technology Breaking News, “New Molecule Could Help Treat Anemia”
  • Highlighted in Medical News Observer, “Hinokitiol, molecule from Japanese cypress tree shows promise in iron related disorders”
  • Highlighted in Health Research Board, “‘Molecular prosthetics’ can exchange lacking proteins to deal with illness”
  • Highlighted in Labroots, “Natural Molecule May Aid in Treatment of Iron Disorders”
  • Highlighted in Big Ten News, “How an Illinois team discovered the world’s first prosthetic molecule”
  • Highlighted in TomoNews, “Molecular prosthetics: Molecule from Japanese tree helps transport iron into cells”
  • Click here to watch a short video with Marty, explaining the molecular prosthetic function of hinokitiol
  1. Palazzolo, A.M.E.; Simons, C.L.W.; Burke, M.D.; “The Natural Productome” Proceedings of the National Academy of Sciences U.S.A. 2017114, 5564-5566.

  1. Gonzalez, J.A; Maduka Ogba, O.; Morehouse, G.F.; Rosson, N.; Houk, K.N.; Leach, A.G.; Cheong, P.H.Y.; Burke, M.D.; Lloyd-Jones, G.C. “MIDA Boronates Are Hydrolysed Fast and Slow by Two Different Mechanisms” Nature Chemistry 20168, 1067-1075.
    [abstract][pdf][supp info]

  • Highlighted in, “Mida boronates react via two different mechanisms”
  1. Davis, S.A.; Della Ripa, L.A.; Hu, L.; Cioffi, A.G.; Rienstra, C.M.; Burke, M.D. “C3-OH of Amphotericin B Plays an Important Role in Ion Conductance” Journal of the American Chemical Society 2015, 137, 15102.[abstract][pdf][supp info]

  1. Endo, M.M.; Cioffi, A.G.; Burke, M.D. “Our Path to Less Toxic Amphotericins” Synlett 2015, 27, 337. Recipient of the Thieme IUPAC Prize in Synthetic Organic Chemistry.

  1. Cioffi, A. G.; Hou, J.; Grillo, A. S.; Diaz, K. A.; Burke, M. D. “Restored physiology in protein-deficient yeast by a small molecule channelJournal of the American Chemical Society 2015, 137, 10096−10099. Recipient of the Thieme IUPAC Prize in Synthetic Organic Chemistry.

  • Highlighted in Cystic Fibrosis News, “New Cystic Fibrosis Research Focused on Small Molecules Interaction with Yeast”.
  • Highlighted in Lung Disease News, “Researchers Investigate a Better Way to Address the Root Cause of Cystic Fibrosis”
  • Highlighted in Medical News Today, “Cystic fibrosis: yeast study may address root cause”
  • Highlighted in News Medical, “Researchers explore better way to address the root cause of cystic fibrosis”
  • Highlighted in Doctor Pulse, “Therapeutic Approach to Tackle the Cause Cystic Fibrosis”
  • Also highlighted in Phys.orgScience Daily, and Eureka Alert!, “Tackling the Root Cause of Cystic Fibrosis”
  • For highlights on the molecular prosthetics approach, see: Science, “The Synthesis Machine”; U.S. News and World Report, “‘Molecular Prosthetics’ May Give New Hope for Incurable Diseases”; andChemistry and Industry, “Molecular Prosthetics”
  • Click here to watch a webinar with Marty, on making molecular prosthetics with the small molecule synthesizer
  1. Li, J.; Grillo, A. S; Burke, M. D. “From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks” Accounts of Chemical Research 201548, 2297–2307.

  1. Davis, S. A.; Vincent, B. M.; Endo, M. M.; Whitesell, L.; Marchillo, K.; Andes, D. R.; Lindquist, S.; Burke, M. D. “Nontoxic Antimicrobials that Evade Drug Resistance” Nature Chemical Biology 2015, 11, 481-487.
    [abstract][pdf][supp info]

  1. Li, J.; Ballmer, S. G.; Gillis, E. P.; Fujii, S.; Schmidt, M. J.; Palazzolo, A. M. E.; Lehmann, J. W.; Morehouse, G. F.; Burke, M. D. “Synthesis of Many Different Types of Organic Small Molecules Using One Automated Process” Science 2015347, 1221-1226.
    [abstract][pdf][supp info]

  • Highlighted in Science, “The Synthesis Machine”.
  • This article was chosen to be represented on the cover of Science.
  • Highlighted in Nature, “Complex Molecules Made to Order in Synthesis Machine”.
  • Highlighted in Nature World News, “Molecule-Making Machine Could Speed Up Drug Development”.
  • Highlighted in Chemical & Engineering News, “Machine Automates Assembly of Small Molecules”.
  • Highlighted in HHMI News, “3D Printer for Small Molecules Opens Access to Customized Chemistry”.
  • Highlighted in Illinois NewsScience Daily, and eScience News, “Molecule-Making Machine Simplifies Complex Chemistry”.
  • Highlighted by Phys Org, “3-D Printer for Small Molecules Opens Access to Customized Chemistry”.
  • Highlighted by Scientific American, “Machine Stitches Complex Molecules at Touch of a Button”.
  • Highlighted by New Scientist, “Dial M for Molecule”.
  • Highlighted by medGadget, “Automated Chemist: A Molecule-Making Machine Creates New Compounds”.
  • Highlighted by STGIST, “Scientists Unveil 3D Printer for Small Molecules”.
  • Highighted by Popular Mechanics, “This Chemistry 3D Printer Can Synthesize Molecules from Scratch”.
  • Highlighted by Technology Review Germany, “Die Molekül-Maschine”
  • Highlighted by C&EN Onion, “Rampaging Synthetic Chemists Smash Synthesis Machine”
  • Highlighted in Science News, “Hands-free Chemistry”
  • Highlighted by HNGN, “Molecule-Making Machine Could be the ‘3-D Printer of Chemistry’”.
  • Highlighted by Forbes, “Scientists Hone Synthetic Drugs Based on Mother Nature’s Handiwork”.
  • Highlighted in Huffington Post, “New ‘Molecule-Making Machine’ Could Speed the Development of Life-Saving Drugs”.
  • Highlighted in Die Ziet, “Chemie auf Knopfdruck”.
  • Also highlighted by News EverdayDesign & TrendZME ScienceSilicon AngleYibada,Engineering.comMake Magazine3D PrintGizMagEcumenical News, and International Business Times.
  • Click here for a YouTube video of Marty describing this advance.
  • Click here to watch a webinar with Marty, on making molecular prosthetics with the small molecule synthesizer
  • Listen to a Science Update on “Do-It-Yourself Molecules” describing this advance.
  1. Woerly, E. M.; Roy, J.; Burke, M. D. “Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction” Nature Chemistry 2014, 6, 484-491.
    [abstract][pdf][supp info]

  • Highlighted in Nature, “Simple Recipe for Small Molecules”.
  • Highlighted in Nature Chemistry, “Natural Products on Demand”.
  • Highlighted in Nature Chemical Biology, “A Plethora of Polyenes”.
  • Highlighted in Chemical & Engineering News, “Easier Route to Polyenes”.
  • Highlighted in Genetic and Engineering News, “LEGO-Style CHemistry to Build Thousands of Small Molecule Drug Candidates”.
  • Highlighted by My Science, “Making Better Medicines with a Handful of Chemical Building Blocks”.
  • Click here for a YouTube video of Marty describing this advance.
  1. Anderson, T. M.; Clay, M. C.; Cioffi, A. G.; Diaz, K. A.; Hisao, G. S.; Tuttle, M. D.; Nieuwkoop, A. J.; Comellas, G.; Wang, S.; Uno, B. E.; Wildeman, E. L.; Maryum, N.; Gonen, T.; Rienstra, C. M.; Burke, M. D. “Amphotericin Forms an Extramembranous and Fungicidal Sterol Sponge” Nature Chemical Biology2014, 10, 400-406.
    [abstract][pdf][supp info]

  • Highlighted in Nature Chemical Biology, “A Sponge against Fungal Infections”.
  • Highlighted by Illinois News describing the elucidation of amphotericin’s biological activity.
  • Also highlighted in Science Newsline,, Science Daily, Health Canal, and Chemistry Views.
  1. Wilcock, B. C.; Endo, M. M.; Uno, B. E.; Burke, M. D. “C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells” Journal of the American Chemical Society 2013135, 8488-8491.
    [abstract][pdf][supp info]

  • Highlighted in C&EN News describing its potential as “A Less Toxic Antifungal Agent”.
  1. Woerly, E. M.; Miller, J. E.; Burke, M. D. “(1-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis” Tetrahedron Special Issue in Honor of Professor Paul Wender for receipt of the Tetrahedron Award 2013, 69, 7732-7740.

  1. Wilcock, B. C.; Uno, B. E.; Bromann, G. L.; Clark, M. J.; Anderson, T. M.; Burke, M. D. “Electronic tuning of site-selectivity” Nature Chemistry 20124, 996-1003.
    [abstract][pdf][supp info]

  1. K.C. Gray, D.S. Palacios, I. Dailey, M.M. Endo, B.E. Uno, B.C. Wilcock, M.D. Burke. “Amphotericin primarily kills yeast by simply binding ergosterol” Proceedings of the National Academy of Sciences U.S.A. 2012109, 2234-2239.
    [abstract][pdf][supp info]

  1. G.R. Dick, E.M. Woerly, M.D. Burke. “A General Solution for the 2-Pyridyl Problem” Angewandte Chemie International Edition 201251, 2667-2672 .
    [abstract][pdf][supp info]

  1. J. Li, M.D. Burke. “Pinene-Derived Iminodiacetic Acid (PIDA): A Powerful Ligand for Stereoselective Synthesis and Iterative Cross-Coupling of C(sp3) Boronate Building Blocks” Journal of the American Chemical Society 2011133, 13774-13777.
    [abstract][pdf][supp info]

  1. S. Fujii, S.Y. Chang, M.D. Burke. “Total Synthesis of Synechoxanthin through Iterative Cross-Coupling”Angewandte Chemie International Edition 201150, 7862-7864.
    [abstract][pdf][supp info]

  • Highlighted on the cover of Angew. Chem. August, 16 2011; Volume 50, Issue 34.
  • Highlighted in Chemistry World.
  • Highlighted in Illinois News.
  1. D.S. Palacios, I. Dailey, D.M. Siebert, B.C. Wilcock, M.D. Burke. “Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities”Proceedings of the National Academy of Sciences U.S.A. 2011108, 6733-6738.
    [abstract][pdf][supp info]

Publication 22

  1. E.M. Woerly, J.R. Struble, N. Palyam, S.P. O’Hara, M.D. Burke. “(Z)-(2-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis” Tetrahedron: Special Issue in honor of Professor Dean Toste for receipt of the Tetrahedron Young Investigator Award 2011,67, 4333-4343.

Publication 21

  1. S.J. Lee, T.M. Anderson, M.D. Burke. “A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling” Angewandte Chemie International Edition201049, 8860-8863.
    [abstract][pdf][supp info]

Publication 19

E.M. Woerly, A.H. Cherney, E.K. Davis, M.D. Burke. “Stereoretentive Suzuki-Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (-)-Peridinin” Journal of the American Chemical Society 2010132, 6941-6943.
[abstract][pdf][supp info]

Publication 18

  1. G.R. Dick, D.M. Knapp, E.P. Gillis, M.D. Burke. “General Method for Synthesis of 2-Heterocyclic N-Methyliminodiacetic Acid Boronates” Organic Letters 201012, 2314-2317.
    [abstract][pdf][supp info]

Publication 17

  1. J.R. Struble, S.J. Lee, M.D. Burke. “Ethynyl MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis.” Tetrahedron: Special Issue in honor of Professor Brian Stoltz for receipt of the Tetrahedron Young Investigator Award201066, 4710-4718.
    [abstract] [pdf]

Publication 16

  1. I.A. Dailey, M.D. Burke. “N-(Carboxymethyl)-N-methyl-glycine.” Encyclopedia of Reagents for Organic Synthesis2010.
    [abstract] [pdf]
  1. S.G. Ballmer, E.P. Gillis, M.D. Burke. “B-Protected Haloboronic Acids for Iterative Cross-Coupling”Organic Syntheses 200986, 344-359.

Publication 15

  1. E.P. Gillis, M.D. Burke. “Iterative Cross-Coupling with MIDA Boronates: Towards a General Strategy for Small Molecule Synthesis,” Aldrichimica Acta200942, 17-27.

Publication 14

  1. D.M. Knapp, E.P. Gillis, M.D. Burke. “A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates.” Journal of the American Chemical Society 2009131, 6961-6963.
    [abstract][pdf][supp info]

Publication 13

  • Highlighted in Chemical and Engineering News.
  • One of the top 10 “Most Read” articles in Journal of the American Chemical Society, May-June 2009
  • Highlighted in Angewandte Chemie International Edition
  • For Prof. Richard Taylor’s application of this methodology in the total synthesis of dictyosphaeric acid A, see Angewandte Chemie International Edition 201049, 5574-5577.
  • For Prof. Jon Ellman’s recent development of asymmetric additions to aldimines via slow-release with MIDA boronates, see The Journal of Organic Chemistry 201075, 3147-3150.
  • For an application of this latter methodology to the total synthesis of aurantioclavine, see Organic Letters 201012, 2004-2007.
  1. B.E. Uno, E.P. Gillis, M.D. Burke. “Vinyl MIDA Boronate: a readily accessible and highly versatile building block for small molecule synthesis” Tetrahedron: Special Issue dedicated to Professor Justin Dubois’ receipt of the 2008 Tetrahedron Young Investigator Award, Tetrahedron 200965, 3130-3138.

Publication 11

  1. E.P. Gillis, M.D. Burke. “Multistep Synthesis of Complex Boronic Acids from Simple MIDA Boronates”Journal of the American Chemical Society 2008130, 14084-14085.
    [abstract][pdf][supp info]

Publication 10

  1. S.J. Lee, K.C. Gray, J.S. Paek, M.D. Burke. “Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling” Journal of the American Chemical Society 2008130, 466-468. [abstract][pdf][supp info]

Publication 9

  • Highlighted in Angewandte Chemie International Edition “Controlled Iterative Cross-Coupling: On the Way to the Automation of Organic Synthesis” 200948,5240-5244.
  • Highlighted in Angewandte Chemie International Edition Devising boron reagents for orthogonal functionalization through Suzuki-Miyaura cross-coupling,” 200948, 3565-3568
  • Highlighted in the 3 November 2008 issue of Chemistry World
  • Highlighted in the 20 December 2007 issue of Chemistry World
  • Highlighted in Chemistry and Industry
  • Highlighted in SynForm.
  • Reviewed in Accounts of Chemical Research 200841, 1461-1473
  • Included in a new textbook “Organometallics” authored by Professor John Wolfe.
  1. D.S. Palacios, T.M. Anderson, M.D. Burke “A Post-PKS Oxidation of the Amphotericin B Skeleton Predicted to be Critical for Channel Formation is Not Required for Potent Antifungal Activity” Journal of the American Chemical Society 2007129, 13804-13805. [abstract][pdf][supp info]

Publication 8

  • Highlighted in the Jan 1, 2008 issue of Nature Chemical Biology.
  • Highlighted in The Scientist
  • Highlighted in Natural Product Reports 200825, 11-15.
  1. E.P. Gillis and M.D. Burke. “A Simple and Modular Strategy for Small Molecule Synthesis: Iterative Suzuki-Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks.” Journal of the American Chemical Society 2007129, 6716-6717. [abstract][pdf][supp info]

Publication 7

  1. M.D. Burke. “Molecular Prosthetics: Replicating the Functions of the Molecules of Life” Enhancing Chemistry Conference sponsored by the American Chemical Society. University of Illinois at Urbana-Champaign, Urbana, Illinois, March 17, 2006.

  1. M.D. Burke, E.M. Berger, and S.L. Schreiber. “A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially.” Journal of the American Chemical Society 2004126, 14095-14104.
  1. M.D. Burke and S.L. Schreiber. “A Planning Strategy for Diversity-Oriented Synthesis.”Angewandte Chemie International Edition 200443, 46-58.

This paper has been recognized by Thomson – ISI as “one of the most cited recent papers in the field of chemistry.” ISI Essential Science Indicators (>1500 citations).

  1. M.D. Burke, E.M. Berger, and S.L. Schreiber. “Generating Diverse Skeletons of Small Molecules Combinatorially.” Science 2003302, 613-618.

This paper was selected as one of the top Chemistry Highlights 2003 “for making natural-product-like libraries of unprecedented diversity.” Chemical & Engineering News 200381:51, 48. For additional commentaries see: Chemical & Engineering News 2003, 81:43, 40; Nature Reviews Drug Discovery “Highlights,” 20032:12, 948; Chemical & Engineering News 200482:40, 32. This work has also been reviewed in Nature2004432, 846-854.

  1. R.M. Kohli, M.D. Burke, X.L. Tao, and C.T. Walsh. “Chemoenzymatic Route to Macrocyclic Hybrid Peptide/Polyketide-like Molecules.” Journal of the American Chemical Society 2003125, 7160-7161.
  1. M.C. White, M.D. Burke, S. Peleg, P. Dolan, T. Kensler, H. Brem, and G.H. Posner. “Conformationally Restricted Hybrid Analogs of 1,25-Dihydroxyvitamin D3, Design, Synthesis, and Preliminary Biological Evaluation.” Bioorganic & Medicinal Chemistry 20019, 1691-1699.
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