Closed-loop transfer enables artificial intelligence to yield chemical knowledge, Nicholas H. Angello, David M. Friday, Changhyun Hwang, Seungjoo Yi, Austin H. Cheng, Tiara C. Torres-Flores, Edward R. Jira, Wesley Wang, Alan Aspuru-Guzik, Martin D. Burke, Charles M. Schroeder, Ying Diao, Nicholas E. Jackson, Nature, 2024. DOI: 1038/s41586-024-07892-1

Delocalized, asynchronous, closed-loop discovery of organic laser emitters, Felix Strieth-Kalthoff, Han Hao, Vandana Rathore, Joshua Derasp, Theophile Gaudin, Nicholas H. Angello, Martin Seifrid, Ekaterina Trushina, Mason Guy, Junliang Liu, Xun Tang, Masashi Mamada, Wesley Wang, Tuul Tsagaantsooj, Cyrille Lavigne, Robert Pollice, Tony C. Wu, Kazuhiro Hotta, Leticia Bodo, Shangyu Li, Mohammad Haddadnia, Agnieszka Wołos, Rafal Roszak, Cher Tian Ser, Carlota Bozal-Ginesta, Riley J. Hickman, Jenya Vestfrid, Andres Aguilar-Granda, Elena L. Klimareva, Ralph C. Sigerson, Wenduan Hou, Daniel Gahler, Slawomir Lach, Adrian Warzybok, Oleg Borodin, Simon Rohrbach, Benjamin Sanchez-Lengeling, Chihaya Adachi*, Bartosz A. Grzybowski*, Leroy Cronin*, Jason E. Hein*, Martin D. Burke*, Alan Aspuru-Guzik, Science, 2024. DOI: 10.1126/science.adk9227

Computational prediction of complex cationic rearrangement outcomes, Tomasz Klucznik, Leonidas-Dimitrios Syntrivanis, Sebastian Baś, Barbara Mikulak-Klucznik, Martyna Moskal, Sara Szymkuć, Jacek Mlynarski, Louis Gadina, Wiktor Beker, Martin D. Burke, Konrad Tiefenbacher, Bartosz A. Grzybowski, Nature, 2024. DOI: 10.1038/s41586-023-06854-3

Rapid automated iterative small molecule synthesis, Wesley Wang, Nicholas H. Angello, Daniel J. Blair, Theodore Tyrikos-Ergas, William H. Krueger, Kameron N.S. Medine, Antonio J. LaPorte, Joshua M. Berger, Martin D. Burke, Nature Synthesis, 2024. DOI: 1038/s44160-024-00558-w

Minimizing higher-order aggregation maximizes iron mobilization by small molecules, Andrew D. Blake, Jianhua Chao, Anna M. SantaMaria, Stella Ekaputri, Kelsie J. Green, Samantha T. Brown, Christopher K. Rakowski, Eun-Kyung Choi, Luisa Aring, Peng-Jui Chen, Nicholas M. Snead, Douglas M. Matje, Tao Geng, Angela Octaviani, Keith Bailey, Stanley J. Hollenbach, Timothy M. Fan, Young-Ah Seo, Martin D. Burke, Nature Chemical Biology, 2024. DOI: 10.1038/s41589-024-01596-3

Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal, Arun Maji, Corinne P. Soutar, Jiabao Zhang, Agnieszka Lewandowska, Brice E. Uno, Su Yan, Yogesh Shelke, Ganesh Murhade, Evgeny Nimerovsky, Collin G. Borcik, Andres S. Arango, Justin D. Lange, Jonnathan P. Marin-Toledo, Yinghuan Lyu, Keith L. Bailey, Patrick J. Roady, Jordan T. Holler, Anuj Khandelwal, Anna M. SantaMaria, Hiram Sanchez, Praveen R. Juvvadi, Gina Johns, Michael J. Hageman, Joanna Krise, Teclegiorgis Gebremariam, Eman G. Youssef, Ken Bartizal, Kieren A. Marr, William J. Steinbach, Ashraf S. Ibrahim, Thomas F. Patterson, Nathan P. Wiederhold, David R. Andes, Taras V. Pogorelov, Charles D. Schwieters, Timothy M. Fan, Chad M. Rienstra, Martin D. Burke, Nature, 2023. DOI: 1038/s41586-023-06710-4.

Closed-loop optimization of general reaction conditions for heteroaryl Suzuki-Miyaura coupling, Nicholas H. Angello, Vandana Rathore, Wiktor Beker, Agnieszka Wołos, Edward R. Jira, Rafał Roszak, Tony C. Wu, Charles M. Schroeder, Alán Aspuru-Guzik, Bartosz A. Grzybowski, Martin D. Burke, Science, 2022. DOI: 10.1126/science.adc8743

A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages, Stella Ekaputria, Eun-Kyung Choi, Manuela Sabelli, Luisa Aring, Kelsie J. Green, JuOae Chang, Kai Bao, Hak Soo Choi, Shigeki Iwase, Jonghan Kim, Elena Corradini, Antonello Pietrangelo, Martin D. Burke, Young Ah Seo, Proceedings of the National Academy of Sciences U.S.A., 2022. DOI: 10.1073/pnas.2121400119

Using automated synthesis to understand the role of side chains on molecular charge transport, Songsong Li, Edward R. Jira, Nicholas H. Angello, Jialing Li, Hao Yu, Jeffrey S. Moore, Ying Diao, Martin D. Burke, Charles M. Schroeder, Nature Communications, 2022. DOI: 10.1038/s41467-022-29796-2

Automated iterative Csp3-C bond formation, Daniel J. Blair, Sriyankari Chitti, Melanie Trobe, David M. Kostyra, Hannah M. S. Haley, Richard L. Hansen, Steve G. Ballmer, Toby J. Woods, Wesley Wang, Vikram Mubayi, Michael J. Schmidt, Robert W. Pipal, Greg. F. Morehouse, Andrea M. E. Palazzolo Ray, Danielle L. Gray, Adrian L. Gill, Martin D. Burke, Nature, 2022. DOI: 10.1038/s41586-022-04491-w

Fungicidal Amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes, Agnieszka Lewandowska, Corinne P. Soutar, Alexander I. Greenwood, Evgeny Nimerovsky, Ashley M. De Lio, Jordan T. Holler, Grant S. Hisao, Anuj Khandelwal, Jiabao Zhang, Anna M. SantaMaria, Charles D. Schwieters, Taras V. Pogorelov, Martin D. Burke & Chad M. Rienstra, Nature Structural & Molecular Biology, 2021. DOI: 10.1038/s41594-021-00685-4

Sterol sponge mechanism is conserved for glycosylated polyene macrolides, Xiaorui Guo, Jiabao Zhang, Xinyi Li, Emily Xiao, Justin D. Lange, Chad M. Rienstra, Martin D. Burke, Douglas A. Mitchell, ACS Central Science, 2021. DOI: 10.1021/acscentsci.1c00148

Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids, Jonathan W. Lehmann, Ian T. Crouch, Daniel J. Blair, Melanie Trobe, Pulin Wang, Junqi Li, Martin D. Burke, Nature Communications, 2019. DOI: 10.1038/s41467-019-09249-z

Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia, Katrina A. Muraglia, Rajeev S. Chorghade, Bo Ram Kim, Xiao Xiao Tang, Viral S. Shah, Anthony S. Grillo, Page N. Daniels, Alexander G. Cioffi, Philip H. Karp, Lingyang Zhu, Michael J. Welsh, Martin D. Burke, Nature, 2019. DOI: 10.1038/s41586-019-1018-5

The molecular industrial revolution: automated synthesis of small molecules, Melanie Trobe and Martin D. Burke, Angewandte Chemie, 2018. DOI: 10.1002/anie.201710482

Towards the generalized iterative synthesis of small molecules, Jonathan W. Lehmann, Daniel J. Blair and Martin D. Burke Nature Reviews Chemistry, 2018. DOI: 10.1038/s41570-018-0115

Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals, Anthony S. Grillo, Anna M. SantaMaria, Martin D. Kafina, Alexander G. Cioffi, Nicholas C. Huston, Murui Han, Young Ah Seo, Yvette Y. Yien, Christopher Nardone, Archita V. Menon, James Fan, Dillon C. Svoboda, Jacob B. Anderson, John D. Hong, Bruno G. Nicolau, Kiran Subedi, Andrew A. Gewirth, Marianne Wessling-Resnick, Jonghan Kim, Barry H. Paw, Martin D. Burke, Science, 2017. DOI: 10.1126/science.aah3862

Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel, Alexander G. Cioffi, Jennifer Hou, Anthony S. Grillo, Katrina A. Diaz, Martin D. Burke, Journal of the American Chemical Society, 2015. DOI: 10.1021/jacs.5b05765

Synthesis of many different types of organic small molecules using one automated process, Junqi Li, Steven G. Ballmer, Eric P. Gillis, Seiko Fujii, Michael J. Schmidt, Andrea M. E. Palazzolo, Jonathan W. Lehmann, Greg F. Morehouse, Martin D. Burke, Science, 2015. DOI: 10.1126/science.aaa5414

Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction, Eric M. Woerly, Jahnabi Roy, Martin D. Burke, Nature Chemistry, 2014. DOI: 10.1038/nchem.1947

Amphotericin forms an extramembranous and fungicidal sterol sponge, Thomas M. Anderson, Mary C. Clay, Alexander G. Cioffi, Katrina A. Diaz, Grant S. Hisao, Marcus D. Tuttle, Andrew J. Nieuwkoop, Gemma Comellas, Nashrah Maryum, Shu Wang, Brice E. Uno, Erin L. Wildeman, Tamir Gonen, Chad M. Rienstra, Martin D. Burke, Nature Chemical Biology, 2014. DOI: 10.1038/nchembio.1496

Amphotericin primarily kills yeast by simply binding ergosterol, Kaitlyn C. Gray, Daniel S. Palacios, Ian Dailey, Matthew M. Endo, Brice E. Uno, Brandon C. Wilcock, and Martin D. Burke, Proceedings of the National Academy of Sciences U.S.A., 2012. DOI: 10.1073/pnas.1117280109

Pinene-derived iminodiacetic acid (PIDA): A powerful ligand for stereoselective synthesis and iterative cross-coupling of C(sp3) boronate building block, Junqi Li and Martin D. Burke, Journal of the American Chemical Society, 2011. DOI: 10.1021/ja205912y

A general solution for unstable boronic acids: Slow-release cross-coupling from air-stable MIDA boronates, David M. Knapp, Eric P. Gillis, Martin D. Burke, Journal of the American Chemical Society, 2009. DOI: 10.1021/ja901416p

Multistep synthesis of complex boronic acids from simple MIDA boronates, Eric P. Gillis and Martin D. Burke, Journal of the American Chemical Society, 2008. DOI: 10.1021/ja8063759

Simple, efficient, and modular syntheses of polyene natural products via iterative cross-coupling, Suk Joong Lee, Kaitlyn C. Gray, James S. Paek, and Martin D. Burke, Journal of the American Chemical Society, 2008. DOI: 10.1021/ja078129x

A simple and modular strategy for small molecule synthesis: iterative Suzuki−Miyaura coupling of B-protected haloboronic acid building blocks, Eric P. Gillis and Martin D. Burke, Journal of the American Chemical Society, 2007. DOI: 10.1021/ja0716204